APC and colorectal carcinoma: Figure 3b shows that alteration, mutation, methylation aberrance, and loss of copy number of APC gene may result in CRC initiation, progression, or metastasis. Previous studies have reported that the loss of function, as well as methylation aberrance and mutation of the APC gene, is associated with early events in CRC [83,84,85,86,87,88,89,90,91,92].