In the present study, analysis of ER stress markers eIF2α and p-eIF2α in liver homogenate of WT LS mice and Tff3−/− LS mice with induced stroke demonstrated that Tff3-deficient mice on LS diet had 50% lower activation of p-eIF2α compared to WT controls on a LS diet, suggesting a downregulated ERS response. Here, TFF3 is linked to stroke disorder.