In our previous studies [30,31] we demonstrated that the glyco-gene B4GALT1 expression is downregulated, through hypermethylation, in primary tumors of CRC patients yielding a specificity of 91.7% and a sensitivity of 54% and that it seems to characterize the invasive phenotype of adenocarcinoma, whereas it is significantly less frequently methylated in early lesions such as adenoma. Here, B4GALT1 is linked to colorectal carcinoma.