INS and early-onset autosomal dominant Alzheimer disease: This study evaluates the gene expression of insulin signalling markers involved such as insulin receptor (IR), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), protein kinase B or (AKT), glucose transporter 3 (GLUT3) and glucose transporter 4 (GLUT4); Alzheimer’s disease (AD) markers such as glycogen synthase kinase-3 beta (GSK3β) and tau (TAU).