Analysis of anti-SRC-3 IHC staining of human breast cancer sections from the Protein Atlas collection (www.proteinatlas.org/ENSG00000124151-NCOA3/pathology/breast+cancer) also showed evidence of SRC-3-positive extranuclear budding at a frequency ranging from 2–5% of cells (Supplementary Figure S2). Here, NCOA3 is linked to cancer.