Reduced levels of VEGF and pigment epithelium-derived factor (PEDF, also known as SERPINF1) in AH are associated with response to treatment and disease inactivity [29,30,31]; (d) monitoring the response to anti-VEGF drug treatment of diabetic retinopathy (DR) and diabetic macular edema (DME). This evidence concerns the gene SERPINF1 and diabetic macular edema.