SLC40A1 and Familial prostate cancer: A similar autocrine Fpn regulation by Hepc has been reported in human monocytes, in cardiomyocytes, and in prostate cancer.32, –34 In the primary iron overload mouse models resulting from systemic HepcKO-, Bmp6KO-, and Hepc-resistant Fpn-knockin, all of which harbor defects in the Hepc/Fpn regulatory axis, this hypothesized autocrine loop would be impaired, consistent with the NSR iron accumulation, and lack of rVEC iron accumulation, observed in these models.