SF3B1 and B-cell chronic lymphocytic leukemia: Still, Sf3b1K700E/+ murine models only partially recapitulate the hematopoietic phenotype characteristic of MDS [50,51] and CLL [52], although a modest overlap in aberrant splicing events between Sf3b1K700E/+ mice and MDS patients with SF3B1 mutations was detected [39].