Along with SF3B1 mutations, recurrent missense mutations in U2 small nuclear RNA auxiliary factor 1 (U2AF1) and serine/arginine-rich splicing factor 2 (SRSF2) were discovered in hematological malignancies [2], and later reported to be present in some solid tumors [36,37]. The gene discussed is SRSF2; the disease is hematologic disorder.