DGUOK and lung cancer: To investigate this hypothesis, we determined whether DGUOK depletion affected the proportion of CSC in lung cancer cell lines using several markers, including aldehyde dehydrogenase (ALDH) activity (Sullivan et al, 2010; Shao et al, 2014), CD166, CD49, and the side populations (Ho et al, 2007; Zhang et al, 2012, 2017; Bora‐Singhal et al, 2015).