It is interesting to note that DGUOK was also able to activate AMPK and decrease the levels of YAP1 protein in A549 (Fig EV4D), an LKB1 mutant cell line, and the ectopic expression of NDI1 was able to reverse the effect of DGUOK KO, suggesting that the AMPK‐YAP1 signaling axis downstream of DGUOK is conserved between LKB1 mutant and wild‐type lung cancer. Here, AVPR2 is linked to lung carcinoma.