The metabolic rewiring of cancer cells modulates the activity of the energy stress sensor AMP‐activated kinase (AMPK), which in turn controls YAP/TAZ signaling directly (by direct phosphorylation of YAP) or indirectly (by activating LATS1/2 or AMOTL2) (DeRan et al, 2014; Mo et al, 2015; Wang et al, 2015; Santinon et al, 2016). The gene discussed is AMOTL2; the disease is cancer.