The ectopic expression of YAP1‐6SA at least partially restored the lung sphere formation ability and the proportion of ALDH+ CSC in DGUOK KO cells (Figs 4K and L, and EV4E), suggesting that DGUOK depletion inhibits lung cancer cell stemness by inhibiting YAP1 signaling. The gene discussed is LDHA; the disease is lung carcinoma.