DGUOK and neoplasm: Although DGUOK depletion slightly increased cell apoptosis in H1650 cell under adherent conditions (5.8 ± 0.5% in control cells vs. 6.8 ± 0.4% in DGUOK KO cells), there was no difference in apoptosis under sphere‐forming non‐adherent condition (28.1 ± 2.1% in the control vs. 29.8 ± 2.6% in the KO groups) suggesting that the difference in tumor sphere‐forming capacity was not due to anoikis resistance (Fig 2E and F).