Although the molecular basis for the tissue tropism of S. pyogenes strains is not completely understood, three major emm pattern groups, known as A‐C, D and E, based on sequence differences in the conserved 3′ end of emm and flanking emm‐like genes, such as mrp and enn, have been reported to have significant associations with pharyngitis and impetigo (Bessen, 2016). The gene discussed is PIGG; the disease is pharyngitis.