The Hippo signaling pathway is one of the 10 oncogenic signaling pathways with frequent genetic alterations, and Hippo pathway genes such as LATS1/2 and YAP were somatically mutated in 10% of 9,125 tumors across 33 cancers profiled by The Cancer Genome Atlas (Sanchez‐Vega et al, 2018). The gene discussed is LATS1; the disease is cancer.