C1GALT1C1 and cancer: For instance, Huang et al reported that Cosmc overexpression promoted malignant behaviours in cancer cells through induction of aberrant O‐glycosylation, whereas Cosmc knockdown reduced these malignancies, which indeed contradicted most reports.15 Lee et al also showed that overexpression of Cosmc in human umbilical vein endothelial cells enhanced T‐synthase, Tn antigen expression and cell growth.16 Moreover, it is noticeable that in many human cancers expression of Cosmc and Tn antigen is equally elevated,17 which is a paradox hard to explain by the theory of aberrant O‐glycosylation.