HSPA5 and colorectal carcinoma: It has been proposed that expression of Cosmc may be induced by ER stress, which occurs frequently in malignancies.17 Moreover, Tn antigen has been discovered to be abundantly expressed in human CRC, which may promote Cosmc production via a feedback loop.17 To test these possibilities, we examined the expression levels of ER stress markers such as GRP78 and CHOP in another set of frozen CRC tissues (16 normal colorectal tissues, 32 CRC tissues).