VEGFA and wet macular degeneration: For example, the expression of VEGFA may be up‐regulated by lncRNA MALAT1, which targets miR‐145, resulting in the promotion of angiogenesis in brain microvascular endothelial cells.50 In summary, miR‐34a‐5p, miR‐126‐3p, miR‐145‐5p and miR‐205‐5p may regulate cellular inflammation, modifications to both the extracellular matrix and phenotype as well as altering cellular proliferation all of which may contribute to the clinical signs of wet AMD.