TREM2 and age-related macular degeneration: The expression of miR‐34a‐5p may occur in response to oxidative stress, a major factor of AMD pathogenesis.26 miR‐34a‐5p negatively regulates angiogenesis, which is essential for the development of wet AMD.27, 28 The up‐regulation of miR‐34a‐5p was reported to be involved in drusen formation in AMD through the down‐regulation of the triggering receptor expressed in myeloid/microglial cells‐2 (TREM2).29 This receptor is involved in the clearance of the aggregated Aβ42 peptide from the extracellular space.