CYP3A4 and hepatocellular carcinoma: Likewise, Bmal1 knockdown led to downregulation of Cyp3a11/CYP3A4 in various hepatoma and colon carcinoma cell lines (i.e., Hepa1-6, Hepa-1c1c7, CT26, HepG2, and Caco-2) (Fig. 1f, g).