Likewise, Bmal1 knockdown led to downregulation of Cyp3a11/CYP3A4 in various hepatoma and colon carcinoma cell lines (i.e., Hepa1-6, Hepa-1c1c7, CT26, HepG2, and Caco-2) (Fig. 1f, g). This evidence concerns the gene CYP3A4 and colon carcinoma.