Clinical pallor defined by examination of conjunctiva, nail bed and palms of hands or soles of feet was present in 95% of children with profound anaemia (Hb<4g/dl); 77% with Hb 4-6g/dl, and 19% of children Hb>6g/dl (Table 2); jaundice was uncommon (1.9%). The gene discussed is GSTM1; the disease is anemia (phenotype).