Excess mortality in bolus arms was evident in children without severe anaemia (Hb ≥5g/ld.; relative risk 1.31 (95% confidence interval 0.93-1.84)) as well as those severe anaemia (Hb <5g/ld.; RR 1.71 (1.16-2.51)) with no apparent heterogeneity between these sub-groups (p=0.31)13. The gene discussed is GSTM1; the disease is anemia (phenotype).