Evidence from literature abounds with information on the pronucleating factors in bile, such as N‐aminopeptidase, fibronectin, immunoglobulins, acidic glycoproteins, mucin, and lipoproteins.24, 25 Cavalu et al.,26 using a deconvolution procedure, report that the random coils may represent the dominant secondary structure of proteins that may be involved in GS pathogenesis. The gene discussed is MUC5AC; the disease is Gerstmann syndrome.