TGA/chemometric screening test is able to detect hemoglobinopathies determined by both quantitative defects as thalassemias and qualitative defects due to structural hemoglobin variants and not only in presence of hypochromic and microcytic anemia, but also in macrocytic anemia, and conditions that need molecular analysis for diagnosis such as δβ-thalassemia and β-thalassemia combined with Hb Lepore (Risoluti et al., 2016b, 2018a,b, 2019). This evidence concerns the gene GSTM1 and microcytic anemia.