PIK3CA and cancer: Regarding the involvement of miR-363 in cancer development and progression, studies have shown that miR-363 promoted tumor cell proliferation, invasion, and metastasis by regulating not only SP1 and Notch1, but the PIK3CA-PI3K/AKT pathway (Song et al., 2015; Liu et al., 2017; Ying et al., 2017).