Even though CeD specific serology is imperfect test, guidelines recommend to assess CeD serology (anti- tissue transglutaminase; tTG IgA, or DGP IgA) every 3–6 months in the first year after the diagnosis or until stabilization, and then annually in the long term to monitor CeD activity (16). This evidence concerns the gene TGM2 and cranioectodermal dysplasia.