YB-1 protein has been correlated with poor prognosis previously (Shibahara et al., 2001; Gessner et al., 2004), supported by a recent meta-analysis of six studies covering data on 692 NSCLC patients, where YB-1 was associated with worse overall survival, tumor stage and depth of invasion (Jiang et al., 2017). Here, YBX1 is linked to neoplasm.