YB-1 is overexpressed in mesothelioma compared to non-malignant mesothelial cells in vitro (Johnson et al., 2018) and a small study of 33 MPM patients showed a trend toward higher YB-1 expression in sarcomatoid MPM tumors, which are associated with shorter survival (Iwanami et al., 2014). This evidence concerns the gene YBX1 and mesothelioma.