The ability of Myc to transcriptionally activate YBX1 is interesting, not only as Myc drives malignant behavior and is often associated with poor prognosis in thoracic cancers (Jiang et al., 1992; Volm and Koomagi, 2000; Riquelme et al., 2014), but because YB-1 can itself initiate Myc translation by acting as a specific internal ribosome entry segment-trans-activating factor (Cobbold et al., 2010). This evidence concerns the gene MYC and thoracic cancer.