Given the probable importance and frequent upregulation of SOX2 in lung cancer (Rudin et al., 2012; Karachaliou et al., 2013; Friedlaender et al., 2019; Figure 1B), a study investigating the relationship between YB-1 and SOX2 in thoracic cancer may further implicate YB-1 in the biology of these diseases. The gene discussed is YBX1; the disease is lung carcinoma.