SOX2 and small cell lung carcinoma: SOX2 is involved in cell lineage-survival (Friedlaender et al., 2019) and is often upregulated in SCC (Karachaliou et al., 2013; Friedlaender et al., 2019) (60%; Figure 1B), as well as SCLC (Rudin et al., 2012; Karachaliou et al., 2013) and to a lesser degree ADC (Karachaliou et al., 2013).