Cross-talk between YB-1 and XPC (an important player in NER which has significance in lung cancer carcinogenesis and is affected by germline mutation in MPM), results in their assembly at DNA damage sites (Jin et al., 2014; Fomina et al., 2015; Betti et al., 2017; Sears, 2019). The gene discussed is YBX1; the disease is lung cancer.