CCR7 and Epstein-Barr virus infection: CCR7 plays an essential role in B cell trafficking in lymphoid tissue, and its activation has been shown to be strictly dependent on a highly conserved cellular DNA binding factor (CBF1) as a blockade of or a deficiency in this factor results in the repression of immunoglobulin (Ig) expression in the context of EBV infection (Maier et al., 2005, 2006).