To further explain the role of Mst1, Del re et al. reported that elevation of Ras-association domain family 1 isoform A (Rassf1A), a physiological activator of Mst1, is associated with cardiomyocyte apoptosis and cardiac hypertrophy (Oceandy et al., 2009; Del Re et al., 2010). The gene discussed is MST1; the disease is cardiac hypertrophy.