Sha et al. (2017) identified an inherited missense homozygous mutation in CEP135 in an infertile male with MMAF. Immunofluorescence analysis showed that CEP135 localized to the PC in normal spermatozoa, while the patient’s mutated proteins localized elsewhere in the sperm, forming ectopic aggregates in the sperm neck and flagella (Figure 2). The gene discussed is CEP135; the disease is Infertility.