Based on their high affinity for their FcεRI expressed on tumor-resident cells (e.g., tissue mast cells, macrophages) and the lack of inhibitory IgE Fc receptors (present for IgG), IgE antibodies may offer new options over predominant therapeutic IgG molecules (Josephs et al., 2017; Pellizzari et al., 2019). This evidence concerns the gene IGHE and neoplasm.