Correlated with lymph node metastasis, TNM stage, vessel invasion and differentiation, Also, is an independent predictor of OS and progression free survival. Knockdown, inhibits CRC cell proliferation, migration and invasion in vitro and suppress tumor growth and metastasis in nude mice by NNT-AS1-mediated activating of MAPK/Erk signaling pathway and EMT. The gene discussed is NNT; the disease is metastatic malignant neoplasm in the lymph nodes.