Positively correlated with advanced pathological stages, larger tumor sizes, and lymph node metastasis. Knockdown inhibits cell proliferation, induces cell apoptosis and increase G0/G1 cells. DUXAP10 silencing inhibits tumor growth in vivo, also promotes CRC cell growth and reduces cell apoptosis through silencing the expression of p21 and PTEN by binding LSD1. The gene discussed is PTEN; the disease is colorectal carcinoma.