In the case of oxaliplatin CRC treatment, several lncRNAs such as GIHCG (172), LIN00152 (192), MALAT1 (197), H19 (20), and MEG3 (203, 204) promote apoptosis by inducing cytotoxicity by different mechanisms, mainly by axis with miRNAs targeting important genes in cell death behavior. The gene discussed is GIHCG; the disease is colorectal carcinoma.