Interestingly, LncRNAs regulate multiples pathways in CRC as PI3K-AKT signaling pathway, that is regulated by GAS5, promoting apoptosis via GAS5/miR-182-5p/FOXO3a axis (101), as well as, PI3K/AKT/mTOR that is managed through HOTAIR/miR-326/FUT6 axis stimulating CRC (114). This evidence concerns the gene FOXO3 and colorectal carcinoma.