H19 and colorectal carcinoma: H19 mediated Methotrexate resistance via activating Wnt/β-catenin signaling, which help to develop H19 as a promising therapeutic target for MTX resistant CRC. Besides, CAFs promote stemness and Oxa chemoresistance in CRC by transferring exosomal H19 to CRC sensitive cells through sponging miR-141.