Higher TNM grade and the higher occurrence rate of lymphatic metastasis and distant metastasis, and shorter OS. Overexpression, inhibits proliferation, migration and invasion and induces cell apoptosis in vitro, and represses CRC tumor growth in vivo. Also, exerts a tumor-inhibit role in CRC progression through down-regulating YAP1 expression. The gene discussed is YAP1; the disease is colorectal carcinoma.