PTBP2 and neoplasm: Furthermore, MALAT1 regulates proliferation, migration, and promotes tumor growth and metastasis in nude mice (136), this regulation could be through SFPQ and AKAP-9 as MALAT1 interact with SFPQ, hence releasing PTBP2 from the SFPQ/PTBP2 complex, facilitating cell proliferation and migration (147).