LIN00152 confers Oxa and 5-FU chemoresistance by sponging miR-193a-3p by ERBB4 modulation and then inducing the activation of AKT signaling pathway that mediates cell survival and chemoresistance. miR-193a-3p also targets NOTCH1 regulating CRC growth, metastasis, stemness, and chemoresistance. Here, NOTCH1 is linked to colorectal carcinoma.