Symptoms of pruritus resulted associated at t1 with a 0.79-fold change of XPC and with a 1.01-fold change of ZMAT3; at t2 pruritus was associated with a 0.87-fold change of ATM, and a lower BCL2/BAX ratio (respectively, 0.76- vs. 1.15-fold change). The gene discussed is ZMAT3; the disease is Pruritus.