We found the tumor infiltration of memory B cells is statistically different in BC patients with two PBMC transcriptome subtypes (Figure 3), including all BC patients (P = 0.032), ER+ patients (P = 0.027), Luminal-B patients (P = 0.036) and HER2– patients (P = 0.0022). The gene discussed is ESR1; the disease is neoplasm.