Interestingly, in the brains bearing GL261 tumors, not only was CXCR4 phosphorylation increased in the tumor cells with CED, but there was also observably more p-CXCR4 in the surrounding parenchymal tissue, implicating neuroglial cells have a role in possibly other flow-related signaling. The gene discussed is CXCR4; the disease is neoplasm.