CDC42 and Miyoshi myopathy: We believe that CASIN has great applicability for treating drug-resistant MM considering the following points: (1) Cdc42 activity is enhanced in melphalan/bortezomib-resistant MM cells, suggesting that CASIN would likely cause an oncogene addiction-like effect; (2) CASIN only marginally affects healthy human PBMC and human B cells; (3) CASIN has no effect on thymocyte development and T cell homeostasis in mice (29); and (4) CASIN does not cause weight loss and systemic inflammation in steady-state mice and in mice bearing bortezomib-resistant MM cells (data not shown).