MAPK kinase (MEK)/ERK and Janus kinase (JAK)/signal transducer and activator transcription 3 (STAT3) pathways have been reported to mediate CDC28 protein kinase regulatory subunit 1B (CKS1B)-induced drug resistance in aggressive CKS1B-overexpressing MM (11). Here, MAPK1 is linked to Miyoshi myopathy.