Finally, although the use of GnRH analogs, non-peptide GnRH antagonists, and cytotoxic analogs of GnRH requires more clinical trials for their clinical implementation, the hGnRH/hGnRHR system comprises a very promising target for further pharmaceutical development in the treatment of BC, especially for the treatment of advanced stages of this disease. Here, GNRH1 is linked to breast cancer.