[Ac-D2Nal1, D-4Cpa2, D-3Pal3,6, Leu8, D-Ala10]-GnRH-II induce apoptosis in human endometrial (HEC-1A, HEC-1B and Ishikawa), ovarian (OVCAR-3 and EFO-21) and breast cancer cells (MCF-7 and T47-D) (74, 75). This evidence concerns the gene GNRH2 and breast cancer.