CRI parameters, including C-reactive protein (CRP) (Chaturvedi et al., 2010), platelet-to-lymphocyte ratio (PLR) (Dalpiaz et al., 2017), and neutrophil-lymphocyte ratio (NLR) (McNamara et al., 2014), are widely used in cancer patients to guide treatment and predict prognosis. The gene discussed is CRP; the disease is cancer.