ERBB2 and gastric cancer: RAINSTORM was a randomized phase II study in Japan, South Korea, and Taiwan that evaluated the effectiveness of S-1 and oxaliplatin with ramucirumab (n = 96) or placebo (n = 93) as first-line treatment followed by paclitaxel with ramucirumab as a second-line therapy in patients with HER2-nonexpressing advanced GC (NCT02539225) [68]. Ramucirumab was given at the same dose intensity as that given in RAINFALL for the first-line treatment portion of the study then it was decreased to the same dose intensity as that given in RAINBOW in the 2nd-line portion of the study.