Lei et al. compared gene expression patterns among 248 GC from Singaporean patients and identified 3 major subtypes: proliferative (characterized by high genomic instability, TP53 mutations and DNA hypomethylation), metabolic [more sensitive to 5-fluorouracil (5-FU) than other subtypes], and mesenchymal [with features of cancer stem cells; cell lines of this subtype particularly sensitive to inhibitors of phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway] [5]. Here, MTOR is linked to cancer.