Combination of IMAB362 with chemotherapy using epirubicin, oxaliplatin, and capecitabine showed significantly improved PFS and OS versus chemotherapy alone in FAST study, a randomized phase II first-line study in 161 patients with advanced HER2-negative GC expressing CLDN18.2 (≥ 2+ staining intensity with the anti-CLDN18 43-14A monoclonal antibody in ≥ 40% tumor cells) (NCT01630083). Here, ERBB2 is linked to gastric cancer.