The phase II KEYNOTE-059 in advanced GC was a 3-cohort study: cohort 1 enrolled 259 patients with at least two prior lines of therapy to pembrolizumab alone; cohort 2 enrolled 25 patients to first-line pembrolizumab and cisplatin plus 5-FU or capecitabine; cohort 3 enrolled 31 patients with PD-L1 positive tumors to first-line pembrolizumab alone. The gene discussed is CD274; the disease is gastric cancer.