Although, rs2240308 has been associated with hypodontia and cancer in different populations,16,17 in Iranian subjects, this polymorphism was related with decreased risk for CRC.18 The inconsistent results reported in literature are explained by racial differences.17 In Latino populations, genetic studies relating hypodontia and CRC are scarce, although AXIN2 rs2240308 was recently associated with CRC in Mexican population.19 Therefore, identifying and analyzing genetic mutations in CRC and hypodontia can provide relevant information about the biological behavior of both diseases. Here, AXIN2 is linked to Hypodontia.