The Asian ancestry in Colombia and Mexico is <1%.24 Significant differences have been reported in the association between rs2240308 and the risk of cancer for type of cancer and ethnic group.17 Then, while it has been reported that rs2240308 increased the risk of lung cancer especially in Asian population,5 a recent analysis indicated that AXIN2 148 C > T (rs2240308) variant may be associated with decrease lung risk in Asian and Caucasian populations.25 Therefore, further studies in Latin American population should be conducted to explain the association between AXIN2 polymorphisms and CRC. This evidence concerns the gene AXIN2 and cancer.