Somatic mutations in the AXIN-complex proteins associated with degradation of β-catenin or mutations in β-catenin have been found in different tissues with carcinoma, including skin, gastrointestinal, hepatocellular, and ovarian epithelial cancer.4,14 In addition, AXIN2 has also been independently associated with tooth agenesis and non-syndromic cleft lip palate (NSCLP).15 Here, AXIN2 is linked to tooth agenesis.