Compared with normal brain tissue, PCNA, CALCOCO2, ADI1, GPNMB, MTDH, EIF3D, NEDD9, ERCC1 and PLOD1 were up-regulated while ATP6V1E1, VTI1B, ECHS1 and RCAN2 were down-regulated in GBM patients (Supplementary Figure S3). The gene discussed is ECHS1; the disease is glioblastoma.