Strikingly, all of the genes in the identified modules were significantly enriched into ubiquitin mediated proteolysis, protein processing in endoplasmic reticulum (Module 1), endocytosis, synaptic vesicle cycle, inositol phosphate metabolism, phosphatidylinositol signaling system (Module 2), proteoglycans in cancer, protein processing in endoplasmic reticulum, pathways in cancer, HIF-1 signaling pathway, PI3K-Akt signaling pathway, FoxO signaling pathway and apoptosis (Module 3). The gene discussed is AKT1; the disease is cancer.