AKT1 and cancer: Moreover, module analysis of the PPI network suggested that the top three significant modules of the identified miRNA targets network were associated with ubiquitin mediated proteolysis, protein processing in endoplasmic reticulum, endocytosis, synaptic vesicle cycle, inositol phosphate metabolism, phosphatidylinositol signaling system, proteoglycans in cancer, protein processing in endoplasmic reticulum, pathways in cancer, HIF-1 signaling pathway, PI3K-Akt signaling pathway, FoxO signaling pathway and apoptosis.