According to the KEGG pathway analysis (Figure 5B), these 21 key DE mRNAs were mainly enriched in pathways like proteoglycans in cancer, pathways in cancer, microRNAs in cancer, PI3K-Akt signaling pathway, chemokine signaling pathway, VEGF signaling pathway, prostate cancer, cell cycle and FoxO signaling pathway. The gene discussed is VEGFA; the disease is prostate cancer.