STAT3 and nasopharyngeal carcinoma: In the current study, we found that knockdown of CALR could significantly suppress the activation of Stat3 signaling pathway in CNE2 and HONE1 cells, suggesting CALR could activate Stat3, CALR-Stat3 signaling pathway has been involved in the initiation and progress of NPC and the inhibitory roles of LPLUNC1 in NPC, which will be further investigated in the future.