These studies not only validated mutations of known cancer-related genes including TP53, CDKN2A, FAT1, NOTCH1, PIK3CA, EGFR, KMT2D, NFE2L2, but also identified several new recurrent alterations including ZNF750, AJUBA, FAM135B, TET2, XPO1 in ESCC. Here, KMT2D is linked to cancer.