EP300 and esophageal squamous cell carcinoma: And we also found that both mutation of EP300 and high expression of EP300 are associated with poor prognosis in ESCC, which was highly in accordance to Gao' results that EP300-mutated and overexpressed tumors had a dismal overall survival and Li's results showing that high expression EP300 was correlated with aggressive features and poor prognosis 6, 22.