AKT1 and cancer: The pathway enrichment analysis showed that these differentially expressed genes were enriched in the signaling pathways including PI3K-Akt signaling pathway, NF-kappa B signaling pathway, two-component system, pathways in cancer, transcriptional dysregulation in cancer, microRNAs in cancer and EMT indicating that EP300 may contribute to ESCC tumorigenesis via these pathways (Figure 5A).