Since VEGF is an imperative factor in angiogenesis 28, 29, and it has been reported that EGF is an active player in TAM-mediated tumor progress 30, we hypothesized that macrophages that were observed to be more abundant on the peritoneum of GC patients with peritoneal metastasis might be a cellular source of VEGF and EGF. This evidence concerns the gene EGF and neoplasm.