A number of studies have indicated that Ki-67/MKI67 is a predictive marker for tumor deterioration and its expression shows an association with unfavorable prognosis and malignant clinical phenotypes in various cancers, such as bladder cancer 77, non-small cell lung cancer 78, hepatocellular carcinoma 13, cervical cancer 10 and glioma 16. The gene discussed is MKI67; the disease is central nervous system cancer.