KLF6-SV1 is known as the functionally inactive form of the KLF6 gene, and has been involved in numerous human solid cancers 6, including prostate 10, 11, gastric 12, glioma 13, nasopharyngeal 14, hepatocellular 8, 15-17, pancreatic 7, ovarian carcinomas 9 and et al. KLF6-SV1 is a new player in the promotion of tumor growth and dissemination. The gene discussed is KLF6; the disease is central nervous system cancer.