Results from colony formation assay further supported the effect of KLF6-SV1 on the proliferation of NSCLC cells, in which upregulation of KLF6-SV1 significantly increased clonogenicity of SK-MES-1 cells, whereas downregulation of KLF6-SV1 significantly decreased clonogenicity of A549 cells (Fig. 2C). Here, KLF6 is linked to non-small cell lung carcinoma.