To suggest whether the S100A9 and TNC levels have the same discrimination in the diagnosis of early-stage (stages I+II) CRC, the samples from CRC patients were grouped according to the International Union against Cancer (UICC) tumor-node-metastasis (TNM) staging system, and the serum levels in patients with early-stage (stages I+II) CRC were compared to those in BCD patients. Here, TNC is linked to neoplasm.