Similar to the results seen when comparing S100A9 and TNC levels between the CRC and HD groups, S100A9 and TNC levels showed extraordinary performance as differentiating biomarkers (AUC: 0.836 95% CI: 0.793-0.872; AUC: 0.777 95% CI: 0.730-0.819) that were better than the performance of CEA and CA19-9 levels (S100A9 vs CEA, p<0.01; S100A9 vs CA19-9, p<0.01; TNC vs CA19-9, p<0.01). Here, S100A9 is linked to colorectal carcinoma.