In the present study, strong linkage disequilibrium was observed between the three SNPs rs1743963, rs9493857, and rs1763509 in the intron region of SGK1 gene, and haplotype analysis suggests that the haplotype GGA is likely to be involved in the development of depression in CHD patients after Bonferroni adjustment, which may affect RNA splicing, processing, and editing. The gene discussed is SGK1; the disease is depressive disorder.