REN and type 2 diabetes mellitus: These SNPs were reported to have a tight link with multiple disorders, including blood pressure and renin response to dietary salt intake, and type 2 diabetes (Schwab et al., 2008; Luca et al., 2009; Rao et al., 2013; Chu et al., 2015), with the possibility to affect the process of splicing, processing, and editing of mRNA.