Univariate Cox hazard analysis was used to identify individual single genes from 68 TFs that affect the survival of TCGA GBM patients, in which we obtained 12 statistically significant genes: ASCL1, HOXB, HOXC1, LHX2, MEOX2, RARA, RUNX1, SNAI2, SOX4, TCF3, TGIF1, and ZNF22. The gene discussed is SOX4; the disease is glioblastoma.