SIRT3 and infection: SIRT3/5−/− mice were not as ill as SIRT3/5+/+ mice (P = 0.01; Figure 5A) and had 2.3-fold less L. monocytogenes in blood collected 48 h after infection (SIRT3/5+/+ vs. SIRT3/5−/−: 3.5 ± 0.9 × 103 cfu/ml vs. 1.5 ± 0.3 × 103 cfu/ml; median ± SEM; P = 0.005) (Figure 5B).