Going well along with an improved response to infection, SIRT3/5−/− mice had significantly higher blood concentrations of TNF at day 1 (P = 0.001), TNF and IL-1β at day 2 (P = 0.004 and 0.03) and KC/CXCL1 at day 3 (P = 0.05). Here, SIRT3 is linked to infection.