TNF and infection: Albeit not statistically significant, the levels of G-CSF, IL-1α, MCP-1/CCL2, MIP-2/CXCL2 at day 1, G-CSF, KC, MCP-1, and MIP-2 at day 2, and IL-1α, IL-1β, IL-6, IL-10, MCP-1, MIP-2, and TNF at day 3 post-infection were 1.5–4.4-fold higher in SIRT3/5−/− than in SIRT3/5+/+ mice (Figure 5D).