Ig reactive with alpha3(IV)NC1 collagen, the target antigen in Goodpasture's Disease/anti-glomerular basement membrane nephritis, diseases with serologic and clinical overlap with ANCA vasculitis, were detected in several supernatants of TLR7/TLR9-stimulated cultured lung cells from MRL and B6 mice, including cells from vehicle- as well as silica-exposed subjects (not shown). Here, TLR7 is linked to vasculitis.