Altogether, FCGR2/3 association studies suggest that the pathophysiological mechanisms leading to SLE, RA, and Sjögren syndrome may be fundamentally different from the mechanisms leading to KD and ITP, a fact that is supported by the observation that SLE, RA and Sjögren syndrome occur much more frequently in women than in men, whereas in KD and ITP there is a slight predisposition in males. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.