In contrast to these systemic autoimmune disease, no association with a deletion of FCGR3B has been found for Graves' disease or Addison's disease (85), which suggests that these organ-specific autoimmune diseases are not influenced by FCGR3B copy numbers, although one study found an association of increased copies of FCGR3B with the a protection against the skin blistering disease Bullous Pemphigoid (86). The gene discussed is FCGR3B; the disease is primary adrenal insufficiency.