For example, the trastuzumab mediated ADCC of anti-HER2 breast cancer cells is enhanced with FCGR2A-p.166His and FCGR3A-p.176Val, compared to the other alleles (167), and in case of neutrophil-mediated ADCC for FCGR2A-p.166His (187). This evidence concerns the gene FCGR2A and breast carcinoma.