An increase in the level of TGF-β in adipose tissues influences the production of inflammatory mediators, regulation of energy homeostasis, fat mass expansion, and promotion of collagen deposition, which are associated with obesity in animals and humans (Samad et al., 1997; Fain et al., 2005; Lin et al., 2009; Yadav et al., 2011; Sousa-Pinto et al., 2016). Here, TGFB1 is linked to obesity due to melanocortin 4 receptor deficiency.