NOS3 and Hypertension: Furthermore, SDEVs from PE patients or those obtained by the perfusion of placentae from PE patients reduce the production of nitric oxide (NO) from endothelial cells by blocking the synthesis of endothelial nitric oxide synthase (eNOS), contributing to the vascular endothelial dysfunction, hypertension, and proteinuria found in PE patients (Motta-Mejia et al., 2017).