Because the activation of the AIM2/caspase-1/caspase-4/IL-1α axis is responsible for the release of TGF-β from exacerbated COPD-derived PBMCs, in this study, we evaluated the effect of corticosteroids on AIM2 inflammasome-dependent TGF-β release. This evidence concerns the gene CASP1 and chronic obstructive pulmonary disease.