To understand the involvement of the AIM2 inflammasome during different phases of COPD, PBMCs isolated from COPD patients during an exacerbated and subsequently during a stable phase (after hospitalization) were stimulated with an AIM2 inflammasome ligand, Poly dA:dT (1 μg/ml) for 5 (Figure 1A) and 24 h (Figure 1B). This evidence concerns the gene AIM2 and chronic obstructive pulmonary disease.