STAT3 and head and neck squamous cell carcinoma: Baek et al. (2016) evaluated the effect of the drug Resveratrol, a known suppressor of STAT3 signaling, on apoptosis induction and radiosensitization in SCCHN. They found that Resveratrol induces the expression of the SOCS1 protein and also its mRNA, which blocks the STAT3 signaling pathway, induces apoptosis and even enhances the rate of apoptosis when combined with IR (Baek et al., 2016).