FBXW7 and neoplasm: Fbxw7 has been previously found responsible for the ubiquitylation and subsequent degradation of a set of oncoproteins such as cyclin E, c-Jun and c-Myc via K48 linkage, which earned Fbxw7 recognition as a tumor suppressor (Nakayama and Nakayama, 2006; Welcker and Clurman, 2008).